by
Gail SkowronGail Skowron

Reverse Transcriptase Inhibitors in AIDS Therapy covers the discovery and development of reverse transcriptase drugs and others inhibiting the same viral target from a therapeutic perspective. The early chapters describe the role of reverse transcriptase in the viral lifecycle and structural work that has led to a greater understanding of mechanism and resistance. The discovery and development of six nucleoside analogs are described in the next chapters. Among these are drugs representing milestones in treatment history, such as the benefit of combination therapy, as well as milestones in pharmaceutical manufacturing, such as co-formulation. The inescapable topics of toxicities and resistance to this class are described in subsequent chapters. The non-nucleoside reverse transcriptase inhibitors are described in a similar fashion in general terms and two chapters discuss these agents with respect to pharmacokinetics and comparative clinical efficacy. New reverse transcriptase inhibitors in all classes in various stages of development are described in a chapter and the impact of the approved agents on treatment in general and on vertical transmission in the developing world are dealt with in the final chapters of the book.

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